Italian architect (Rome 1808 - 1882). L. Poletti's pupil and collaborator, he was one of the most active architects in Rome in the last century; his production started to become freer from the initial neoclassicism to express itself in early sixteenth century shapes that mark the passage to architectonic eclecticism. He built Porta S. Pancrazio (1857) , Porta Pia's outer façade (1868), the entrance to the Verano cemetery, the churches of Sacro Cuore in Via Marsala and S. Tommaso di Canterbury, etc. He also engaged in the restoration of medieval buildings, not always with good results: S. Maria Maggiore's confessional (iter 3), presbytery of S. Maria in Trastevere (iter 5), church of S. Marcello in via del Corso, ecc .).

His son Francesco Vespignani (Rome 1842 - 1899) was also an architect, author, in Rome, of the churches of S. Anselmo sull'Aventino and of Sacro Cuore in Via S. Lorenzo .